what is PDRN?
PDRN mesotherapy is a cutting-edge skin rejuvenation treatment designed to repair and restore skin at a cellular level. Known globally for its regenerative properties. Rejuran® PDRN Skin Booster is a treatment formulated with polynucleotides (PN)—biocompatible DNA fragments derived from salmon DNA that closely resemble human DNA. These polynucleotides stimulate skin repair, enhance cellular regeneration, and support collagen production.
Rather than adding volume, Rejuran® focuses on skin healing and quality improvement, making it ideal for patients seeking refinement rather than augmentation.
What areas can you treat with PRFM?
Rejuran® treatments are commonly used to improve:
- Face (post microneedling or mesotherapy injections for overall skin quality and texture)
- Under-eye area
- Neck and décolletage
- Hands
- Acne scars
- Fine lines and crepey skin
Rejuran® is particularly well-suited for delicate areas where subtle, regenerative improvement is desired.
How does rejuran work?
Rejuran® skin booster works by:
- Results develop gradually as the skin repairs itself from within.
- Activating fibroblasts to stimulate collagen and elastin production
- Improving skin barrier function
- Enhancing hydration and elasticity
- Supporting long-term skin regeneration
Benefits of PDRN Treatment
Improves skin texture, tone, and elasticity
Enhances hydration and skin resilience
Stimulates natural collagen production
Non-volumizing, regenerative treatment
Suitable for all skin types
Our approach emphasizes biologic repair and refined, natural-looking results.
cost of dermal filler Treatment
Rejuran® Healing Essence Injectable Mesotherapy: $950/session(Includes 2 syringes) or $2650 for 3 sessions
Rejuran® Skin Booster with microneedling: $675/session or $1875 for 3 sessions (Best for overall skin health)
Rejuran® Tone-Up Booster with microneedling: $700/session or $1950 for sessions (Best for brighetning and even skin tone)
what to expect AFTER Treatment
Discomfort: mild to moderate, microneedling treatments are generally more comfortable compared to mesotherapy
Downtime: mild redness, bruising and injection papules for 1-2 days
Results: starts working at 4 weeks, peaks at 3-4 months, lasts 6-12 months
A series of 3–4 treatments, spaced several weeks apart, is commonly recommended.
HOW TO PREPARE…
PRE-APPOINTMENT
Avoid booking an appointment if you are pregnant.
Avoid blood-thinning medications and supplements (such as aspirin, ibuprofen, fish oil, and vitamin E) for several days prior to treatment unless prescribed by your physician.
Arrive with clean skin and avoid active skincare products (retinoids, exfoliants) for several days before treatment.
DURING APPOINTMENT
Your provider will assess skin quality, concerns, and goals.
Rejuran® is delivered through microinjections into the superficial dermis or through microneedling.
Post mesotherapy, mild redness, swelling, or small injection bumps may occur and usually resolve within 24–72 hours. Post-microneedling, mild redneess and swelling may occur and usually resolve within 24-48 hours.
POST-APPOINTMENT
Avoid touching or applying pressure to treated areas unless instructed
Avoid exercise and other strenuous activity for 24 hours.
Avoid alcohol for 24 hours.
Avoid excessive heat (saunas, hot tubs, sun exposure) for 24–48 hours.
Avoid retinols or exfoliants for one week after microneedling.
Ready to Schedule?
If you’re still not sure, schedule a consultation with one of our board certified providers.
FREQUENTLY ASKED QUESTIONS
Rejuran is a regenerative injectable or topical treatment made from polynucleotides (PN/PDRN) derived from salmon DNA. It is designed to repair damaged skin, improve elasticity, enhance hydration, and restore overall skin health. Rejuran is often referred to as a “skin healer” rather than a traditional filler.
Rejuran works at a cellular level by stimulating skin regeneration and repair. The polynucleotides help improve fibroblast activity, promote collagen production, enhance skin barrier function, and reduce inflammation. This results in healthier, stronger, and more resilient skin over time.
Good candidates are adults looking to improve skin texture, fine lines, elasticity, acne scarring, enlarged pores, or overall skin quality. Rejuran is ideal for patients who want natural-looking skin rejuvenation without adding volume. Schedule a consultation to determine if Rejuran is appropriate for you.
Results develop gradually and improve with a series of treatments. Many patients complete 2–4 sessions spaced several weeks apart, with results lasting 6–12 months. Maintenance treatments may be recommended to sustain optimal skin health.
Downtime is minimal to moderate. Patients may experience redness, swelling, small bumps, or mild bruising at injection sites or mild redness and swelling post-microneedling. These effects typically resolve within 1–3 days, though small injection marks may last slightly longer in some areas.
After treatment, you should avoid:
- Touching, massaging, or applying pressure to treated areas unless instructed
- Strenuous exercise for 24–48 hours
- Excessive heat (saunas, hot tubs, sun exposure) for 24–48 hours
- Alcohol for 24 hours
- Retinols or exfoliants for one week after microneedling
Avoid blood-thinning medications and supplements (such as aspirin, ibuprofen, fish oil, and vitamin E) for several days before treatment unless prescribed by your physician. Arrive with clean skin and avoid active skincare products (retinoids, exfoliants) for several days before treatment.
Rejuran injections can cause mild to moderate discomfort due to the nature of the product. Rejuran with microneedling is typically very comfortable. A topical numbing cream is typically applied beforehand to improve comfort. Most patients find the treatment tolerable.
Yes, Rejuran is considered safe when administered by a trained medical professional. Rejuran is FDA-approved for topical use. Polynucleotides have been widely used in aesthetic and regenerative medicine. As with any injectable treatment, potential risks and side effects will be discussed during your consultation.
Your treatment begins with a consultation to assess your skin and goals. After cleansing and numbing the area, Rejuran is either injected using a microinjection technique or microneedled into targeted areas of the skin. The procedure typically takes 30–45 minutes, with gradual improvements over the following weeks as skin regenerates.
